Ginsenoside Rg5 (Standard)

Ginsenoside Rg5 (Standard) is the analytical standard of Ginsenoside Rg5. This product is intended for research and analytical applications. Ginsenoside Rg5 is the main component of Red ginseng and IGF-1R agonist. Ginsenoside Rg5 compets for the binding site of IGF-1R and blocks the binding of IGF-1 to IGF-1R (IC50 about 90 nM) . Ginsenoside Rg5 also inhibits the mRNA expression of COX-2 via suppression of the DNA binding activities of NF-κB p65.

Product Specifications

CAS Number

[186763-78-0]

UNSPSC

12352005

Target

COX; IGF-1R; NF-κB; Reference Standards

Type

Reference Standards

Related Pathways

Immunology/Inflammation; NF-κB; Others; Protein Tyrosine Kinase/RTK

Field of Research

Cancer; Inflammation/Immunology; Cardiovascular Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/ginsenoside-rg5-standard.html

Smiles

C[C@@]([C@@]12C)(CC[C@@]3([H])C4(C)C)[C@@](C[C@@H](O)[C@]1([H])[C@@H](/C(C)=C/C/C=C(C)\C)CC2)([H])[C@]3(CC[C@@H]4O[C@@](O[C@H](CO)[C@@H](O)[C@@H]5O)([H])[C@@H]5O[C@]([C@@H]([C@@H](O)[C@@H]6O)O)([H])O[C@@H]6CO)C

Molecular Formula

C42H70O12

Molecular Weight

767.00

References & Citations

[1]Cho YL, et al. Specific activation of insulin-like growth factor-1 receptor by ginsenoside Rg5 promotes angiogenesis and vasorelaxation. J Biol Chem. 2015 Jan 2;290 (1) :467-77.|[2]Li W, et al. Ginsenoside Rg5 Ameliorates Cisplatin-Induced Nephrotoxicity in Mice through Inhibition of Inflammation, Oxidative Stress, and Apoptosis. Nutrients. 2016 Sep 13;8 (9) . pii: E566.|[3]Kim SJ, et al. Anti-breast cancer activity of Fine Black ginseng (Panax ginseng Meyer) and ginsenoside Rg5. J Ginseng Res. 2015 Apr;39 (2) :125-34.