Silydianin (Standard)

Silydianin (Standard) is the analytical standard of Silydianin (HY-N0646) . This product is intended for research and analytical applications. Silydianin is a flavonolignan. Silydianin can be obtained from Silybum marianum. Silydianin inhibits PTP1B with an IC50 of 17.38 μM. Silydianin inhibits both monophenolase and diphenolase of tyrosinase significantly, with IC50s of 2.6 μM and 16.5 μM, respectively. Silydianin induces Apoptosis and reduces cytokines (IL-4 and IL-5) . Silymarin has antioxidant, cytoprotective and immunomodulatory effects. Silydianin has antitumor activity against prostate cancer. Silymarin can be used in allergic asthma research[1][2][3][4][5][6][7].

Product Specifications

CAS Number

[29782-68-1]

UNSPSC

12352005

Target

Apoptosis; Endogenous Metabolite; Interleukin Related; Phosphatase; Reference Standards; Tyrosinase

Type

Reference Standards

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; Others

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/silydianin-standard.html

Smiles

O=C1[C@]2([H])C=C([C@@H]3[C@@H](O)C(C4=C(O)C=C(O)C=C4O3)=O)[C@@]5([H])[C@]([C@H]2C6=CC=C(O)C(OC)=C6)([H])CO[C@]51O

Molecular Formula

C25H22O10

Molecular Weight

482.44

References & Citations

[1]Vostálová J, et al. Skin Protective Activity of Silymarin and its Flavonolignans. Molecules. 2019 Mar 14;24 (6) .|[2]Qin N, et al. Identification of flavonolignans from Silybum marianum seeds as allosteric protein tyrosine phosphatase 1B inhibitors. J Enzyme Inhib Med Chem. 2018 Dec;33 (1) :1283-1291.|[3]Zielińska-Przyjemska M, et al. An in vitro study of the protective effect of the flavonoid silydianin against reactive oxygen species. Phytother Res. 2006 Feb;20 (2) :115-9.