Ethyl 2-chloroacetoacetate

Ethyl 2-chloroacetoacetate (A 21960) is a Tn3 resolvase inhibitor, and inhibit synapse formation between resolvase and two directly repeated res sites. Ethyl 2-chloroacetoacetate is commonly used in in vitro enzymatic experiments. Ethyl 2-chloroacetoacetate inhibits the dehalogenation reaction by consuming intracellular GSH in yeast cells[1][2].

Product Specifications

CAS Number

[609-15-4]

Product Name Alternative

A 21960

UNSPSC

12352211

Hazard Statement

H225, H302, H315, H318, H335, H412

Target

Fungal

Type

Reference compound

Related Pathways

Anti-infection

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/ethyl-2-chloroacetoacetate.html

Purity

99.57

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C(C(C)=O)Cl)OCC

Molecular Formula

C6H9ClO3

Molecular Weight

164.59

Precautions

H225, H302, H315, H318, H335, H412

References & Citations

[1]Flanagan PM, et al. Analysis of inhibitors of the site-specific recombination reaction mediated by Tn3 resolvase. J Mol Biol. 1989;206 (2) :295-304. |[2]Jörg G, et al. Fungal aerobic reductive dechlorination of ethyl 2-chloroacetoacetate by Saccharomyces cerevisiae: mechanism of a novel type of microbial dehalogenation. Chembiochem. 2004 Jan 3;5 (1) :87-92.