WLSEAGPVVTVRALRGTGSW (TFA)
Selected Variant
HY-P3436A
Size: 1 Each
WLSEAGPVVTVRALRGTGSW TFA is a cardiomyocyte specific peptide. WLSEAGPVVTVRALRGTGSW-expressing exosomes can improve specific uptake by cardiomyocytes, decrease cardiomyocyte apoptosis, and enhance cardiac retention following intramyocardial injection in vivo[1][2].
Product Specifications
UNSPSC
12352209
Target
Apoptosis
Type
Peptides
Related Pathways
Apoptosis
Applications
Neuroscience-Neurodegeneration
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/wlseagpvvtvralrgtgsw-tfa.html
Solubility
H2O
Smiles
OC(C(F)(F)F)=O.O=C([C@H]1N(CCC1)C(CNC([C@H](C)NC([C@H](CCC(O)=O)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@@H](N)CC2=CNC3=CC=CC=C23)=O)=O)=O)=O)=O)=O)N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H]([C@H](O)C)C(NCC(N[C@@H](CO)C(N[C@H](C(O)=O)CC4=CNC5=CC=CC=C45)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Molecular Formula
C99H153F3N28O29
Molecular Weight
2256.44
References & Citations
[1]McGuire MJ, et, al. In vitro selection of a peptide with high selectivity for cardiomyocytes in vivo. J Mol Biol. 2004 Sep 3;342 (1) :171-82.|[2]Mentkowski KI, et, al. Exosomes Engineered to Express a Cardiomyocyte Binding Peptide Demonstrate Improved Cardiac Retention in Vivo. Sci Rep. 2019 Jul 11;9 (1) :10041.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Price
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