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DY-46-2

DY-46-2 is a high potency and selectivity novel non-nucleoside DNA methyltransferase 3A (DNMT3A) inhibitor with an IC50 value of 0.39 μM[1].

Product Specifications

CAS Number

[1105110-83-5]

UNSPSC

12352005

Target

DNA Methyltransferase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dy-46-2.html

Concentration

10mM

Purity

99.86

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(C1=C(C)OC(N=CN2CCN3CCCC3)=C1C2=O)NC4=CC=C(S(=O)(N)=O)N=C4

Molecular Formula

C19H22N6O5S

Molecular Weight

446.48

References & Citations

[1]J. Yu, et al. Discovery of novel non-nucleoside inhibitors with high potency andselectivity for DNA methyltransferase 3A. European Journal of Medicinal Chemistry (2022) .

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

DNMT3

Available Sizes

Curated Selection

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