Human Tyrosyl-DNA Phosphodiesterase 1

<strong>Human Tyrosyl-DNA Phosphodiesterase 1</strong>_x000D_ <strong>Catalog number:</strong> B2012410_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 5 ug_x000D_ <strong>Molecular Weight or Concentration:</strong> 69.5 kDa_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -20°C_x000D_ <strong>Keywords:</strong> Tyr-DNA phosphodiesterase 1, TDP1, FLJ11090, MGC104252_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Dyrkheeva N, Anarbaev R, Lebedeva N, Kuprushkin M, Kuznetsova A, Kuznetsov N, Rechkunova N, Lavrik O. Human Tyrosyl-DNA Phosphodiesterase 1 Possesses Transphosphooligonucleotidation Activity With Primary Alcohols Front Cell Dev Biol. 2020 Dec 23;8:604732._x000D_ 2: Iyama T, Wilson DM 3rd. DNA repair mechanisms in dividing and non-dividing cells DNA Repair (Amst). 2013 Aug;12(8):620-36._x000D_ 3: Rechkunova NI, Lebedeva NA, Lavrik OI. [Tyrosyl-DNA Phosphodiesterase 1 Is a New Player in Repair of Apurinic/Apyrimidinic Sites] Bioorg Khim. 2015 Sep-Oct;41(5):531-8._x000D_ 4: Zakharenko AL, Drenichev MS, Dyrkheeva NS, Ivanov GA, Oslovsky VE, Ilina ES, Chernyshova IA, Lavrik OI, Mikhailov SN. Inhibition of Tyrosyl-DNA Phosphodiesterase 1 by Lipophilic Pyrimidine Nucleosides Molecules. 2020 Aug 13;25(16):3694._x000D_ 5: Zakharenko A, Dyrkheeva N, Lavrik O. Dual DNA topoisomerase 1 and tyrosyl-DNA phosphodiesterase 1 inhibition for improved anticancer activity Med Res Rev. 2019 Jul;39(4):1427-1441._x000D_ 6: Pommier Y, Sun Y, Huang SN, Nitiss JL. Roles of eukaryotic topoisomerases in transcription, replication and genomic stability Nat Rev Mol Cell Biol. 2016 Nov;17(11):703-721._x000D_ 7: Lebedeva NA, Rechkunova NI, El-Khamisy SF, Lavrik OI. Tyrosyl-DNA phosphodiesterase 1 initiates repair of apurinic/apyrimidinic sites Biochimie. 2012 Aug;94(8):1749-53._x000D_ 8: Huang SN, Pommier Y, Marchand C. Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) inhibitors Expert Opin Ther Pat. 2011 Sep;21(9):1285-92._x000D_ 9: Beretta GL, Cossa G, Gatti L, Zunino F, Perego P. Tyrosyl-DNA phosphodiesterase 1 targeting for modulation of camptothecin-based treatment Curr Med Chem. 2010;17(15):1500-8._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/27687971">10: Laev SS, Salakhutdinov NF, Lavrik OI. Tyrosyl-DNA phosphodiesterase inhibitors: Progress and potential Bioorg Med Chem. 2016 Nov 1;24(21):5017-5027. </a>_x000D_ _x000D_ <strong>Products Related to Human Tyrosyl-DNA Phosphodiesterase 1 can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>