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B-Raf IN 18

B-Raf IN 18 (compound 26) is a B-Raf inhibitor, with IC50 of 3.8 nM. B-Raf IN 18 can be used in anti-cancer related research[1].

Product Specifications

CAS Number

1244644-50-5

UNSPSC

12352005

Target

Raf

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/b-raf-in-18.html

Smiles

O=S(C1=C(C=CC=C1F)F)(NC2=CC=CC(C3=C(SC(C(C)C)=N3)C4=NC(NC5=CC=C(N=C5)N6CCOCC6)=NC=C4)=C2F)=O

Molecular Formula

C31H28F3N7O3S2

Molecular Weight

667.72

References & Citations

[1]Stellwagen JC, et al. Development of potent B-RafV600E inhibitors containing an arylsulfonamide headgroup. Bioorg Med Chem Lett. 2011 Aug 1;21 (15) :4436-40.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

B-Raf

Available Sizes

Frequently Asked Questions

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