B-Raf IN 18
B-Raf IN 18 (compound 26) is a B-Raf inhibitor, with IC50 of 3.8 nM. B-Raf IN 18 can be used in anti-cancer related research[1].
Product Specifications
CAS Number
1244644-50-5
UNSPSC
12352005
Target
Raf
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/b-raf-in-18.html
Smiles
O=S(C1=C(C=CC=C1F)F)(NC2=CC=CC(C3=C(SC(C(C)C)=N3)C4=NC(NC5=CC=C(N=C5)N6CCOCC6)=NC=C4)=C2F)=O
Molecular Formula
C31H28F3N7O3S2
Molecular Weight
667.72
References & Citations
[1]Stellwagen JC, et al. Development of potent B-RafV600E inhibitors containing an arylsulfonamide headgroup. Bioorg Med Chem Lett. 2011 Aug 1;21 (15) :4436-40.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
B-Raf
Available Sizes
Frequently Asked Questions
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