L-739750
L-739750 is a selective protein farnesyltransferase (PFTase) inhibitor (IC50: 0.4 nM) . PFTase utilizes farnesyl diphosphate to farnesylate the cysteine residue of protein substrates having a C-terminal CAAX motif. L-739750 is a selective CAAX peptidomimetic[1][2].
Product Specifications
CAS Number
160141-08-2
UNSPSC
12352005
Target
Farnesyl Transferase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/l-739750.html
Smiles
O=C([C@H](CCS(=O)(C)=O)NC([C@H](CC1=CC=CC=C1)OC[C@H]([C@H](CC)C)NC[C@H](CS)N)=O)O
Molecular Formula
C23H39N3O6S2
Molecular Weight
517.70
References & Citations
[1]1. Kohl NE, et al. Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice. Proc Natl Acad Sci U S A. 1994 Sep 13;91 (19) :9141-5. |[2]Koblan KS, et al. NMR studies of novel inhibitors bound to farnesyl-protein transferase. Protein Sci. 1995 Apr;4 (4) :681-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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