PROTAC-O4I2
PROTAC-O4I2 is a PROTAC targets splicing factor 3B1 (SF3B1) . PROTAC-O4I2 induces FLAG-SF3B1 degradation with an IC50 value of 0.244 μM in K562 cells. PROTAC-O4I2 also induces cellular apoptosis in K562 WT cells[1].
Product Specifications
CAS Number
[2785323-62-6]
UNSPSC
12352005
Target
Apoptosis; PROTACs; SF3B1
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-o4i2.html
Concentration
10mM
Purity
99.56
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(NCCCCCCNC1=CC=CC2=C1C(N(C2=O)C3CCC(NC3=O)=O)=O)C4=CSC(NC5=CC=C(C=C5)Cl)=N4
Molecular Formula
C29H29ClN6O5S
Molecular Weight
609.10
References & Citations
[1]Rodrigo A Gama-Brambila, et al. A PROTAC targets splicing factor 3B1. Cell Chem Biol. 2021 Nov 18;28 (11) :1616-1627.e8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Available Sizes
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