α-Amylase/α-Glucosidase-IN-11
Product Specifications
UNSPSC Description
α-Amylase/α-Glucosidase-IN-11 (Compound 5d) is a isoxazolidine-isatin hybrid with significant antidiabetic activity. α-Amylase/α-Glucosidase-IN-11 competitively inhibits α-amylase (IC50 = 30.39 μM) and α-glucosidase (IC50 = 65.1 μM), two key digestive enzymes. α-Amylase/α-Glucosidase-IN-11 does not cross the blood-brain barrier[1].
Target Antigen
Amylases; Glycosidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/α-amylase-α-glucosidase-in-11.html
Solubility
10 mM in DMSO
Smiles
O=C(N/N=C1C(NC2=C\1C=CC=C2Cl)=O)COC3=C(C)C=CC=C3C[C@@H]4C[C@]5([H])N([C@]6(N(C)C5=O)[C@H](C(C)C)CC[C@@H](C)C6)O4
Molecular Weight
622.15
References & Citations
[1]Ghannay S, et al. dentification of dual-target isoxazolidine-isatin hybrids with antidiabetic potential: Design, synthesis, in vitro and multiscale molecular modeling approaches. Heliyon. 2024 Feb 11;10(4):e25911.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-162390/α-Amylase-α-Glucosidase-IN-11-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-162390/
Clinical Information
No Development Reported
Curated Selection
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