AZ760
AZ760 is a CCR8 antagonist. AZ760 shows excellent potency, good lipophilicity and high free fraction in blood. AZ760 exhibits unacceptable hERG inhibition[1].
Product Specifications
CAS Number
912461-36-0
UNSPSC
12352005
Target
CCR
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/az760.html
Solubility
10 mM in DMSO
Smiles
O=C(N1CCC2(CCN(CC2)CC3=C(OC4=C(OC)C=CC=C4)C=CC=C3)CC1)C5=[N+]([O-])C=CC=C5
Molecular Formula
C29H33N3O4
Molecular Weight
487.59
References & Citations
[1]Connolly S, et al. Orally bioavailable allosteric CCR8 antagonists inhibit dendritic cell, T cell and eosinophil migration. Biochem Pharmacol. 2012 Mar 15;83 (6) :778-87.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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