EGFR mutant-IN-2
EGFR mutant-IN-2 (Compound D51) is an EGFR mutant inhibitor. EGFR mutant-IN-2 inhibits the EGFRL858R/T790M/C797S mutant with an IC50 value of 14 nM. EGFR mutant-IN-2 inhibits the EGFRdel19/T790M/C797S mutant with an IC50 value of 62 nM. EGFR mutant-IN-2 has favorable PK parameters, safety properties, in vivo stability, and antitumor activity[1].
Product Specifications
CAS Number
2770009-06-6
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-mutant-in-2.html
Purity
97.0
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
FC(F)(F)C1=CN=C(NC2=CC(C=CN3CCN(C)C)=C3C=C2)N=C1C4=CN(S(CC)(=O)=O)C5=C4C=CC=C5
Molecular Formula
C27H27F3N6O2S
Molecular Weight
556.60
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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