Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

EGFR mutant-IN-2

EGFR mutant-IN-2 (Compound D51) is an EGFR mutant inhibitor. EGFR mutant-IN-2 inhibits the EGFRL858R/T790M/C797S mutant with an IC50 value of 14 nM. EGFR mutant-IN-2 inhibits the EGFRdel19/T790M/C797S mutant with an IC50 value of 62 nM. EGFR mutant-IN-2 has favorable PK parameters, safety properties, in vivo stability, and antitumor activity[1].

Product Specifications

CAS Number

2770009-06-6

UNSPSC

12352005

Target

EGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/egfr-mutant-in-2.html

Purity

97.0

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

FC(F)(F)C1=CN=C(NC2=CC(C=CN3CCN(C)C)=C3C=C2)N=C1C4=CN(S(CC)(=O)=O)C5=C4C=CC=C5

Molecular Formula

C27H27F3N6O2S

Molecular Weight

556.60

References & Citations

[1]Dong H, et al. Discovery of Potent and Wild-Type-Sparing Fourth-Generation EGFR Inhibitors for Treatment of Osimertinib-Resistance NSCLC. J Med Chem. 2023 May 25;66 (10) :6849-6868.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

PCR Plates
P9601-N 50 Units/Pack

PCR Plates

Sign In for Pricing
View Details
Phospho-eIF4G (S1108) Recombinant Rabbit monoclonal Antibody
HA750588 100 µL

Phospho-eIF4G (S1108) Recombinant Rabbit monoclonal Antibody

Sign In for Pricing
View Details
ETFA Rabbit Polyclonal Antibody
TA376004 100 µL

ETFA Rabbit Polyclonal Antibody

Sign In for Pricing
View Details
ORP150 Recombinant Rabbit Monoclonal Antibody [JG39-11]
ET7108-84 100 µL

ORP150 Recombinant Rabbit Monoclonal Antibody [JG39-11]

Sign In for Pricing
View Details
Parathyroid Hormone Recombinant Rabbit monoclonal Antibody
HA723823 100 µL

Parathyroid Hormone Recombinant Rabbit monoclonal Antibody

Sign In for Pricing
View Details
Neotame
TRC-N390060-1G 1 g

Neotame

Sign In for Pricing
View Details