Tenofovir Disoproxil (fumarate)

Tenofovir Disoproxil fumarate is a nucleotide reverse transcriptase inhibitor used to treat HIV and chronic Hepatitis B.

Product Specifications

CAS Number

[202138-50-9]

Product Name Alternative

Tenofovir DF; Bis (POC) -PMPA (fumarate) ; GS 4331 (fumarate)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

HBV; HIV; Reverse Transcriptase

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/tenofovir-disoproxil-fumarate.html

Purity

99.65

Solubility

DMSO : ≥ 50 mg/mL|H2O : 10 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(OC(C)C)OCOP(OCOC(OC(C)C)=O)(CO[C@H](C)CN1C=NC2=C(N)N=CN=C12)=O.O=C(O)/C=C/C(O)=O

Molecular Formula

C23H34N5O14P

Molecular Weight

635.51

Precautions

H302, H315, H319, H335

References & Citations

[1]Murphy RA, et al. Establishment of HK-2 Cells as a Relevant Model to Study Tenofovir-Induced Cytotoxicity. Int J Mol Sci. 2017 Mar 1;18 (3) |[2]Musumeci G, et al. M48U1 and Tenofovir combination synergistically inhibits HIV infection in activated PBMCs and human cervicovaginal histocultures. Sci Rep. 2017 Feb 1;7:41018|[3]Wahl A, et al. Predicting HIV Pre-exposure Prophylaxis Efficacy for Women using a Preclinical Pharmacokinetic-Pharmacodynamic In Vivo Model. Sci Rep. 2017 Feb 1;7:41098|[4]Menne S, Cote PJ, Korba BE, Antiviral effect of oral administration of tenofovir disoproxil fumarate in woodchucks with chronic woodchuck hepatitis virus infection. Antimicrob Agents Chemother. 2005 Jul;49 (7) :2720-8.|[5]Xu P, et al. Combined Medication of Antiretroviral Drugs Tenofovir Disoproxil Fumarate, Emtricitabine, and Raltegravir Reduces Neural Progenitor Cell Proliferation In Vivo and In Vitro. J Neuroimmune Pharmacol. 2017 Dec;12 (4) :682-692.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

HIV-1

Citation 01

Adv Sci (Weinh) . 2024 Aug 19:e2403058.|Cell. 2025 Sep 4;188 (18) :4896-4912.e19.|Int J Antimicrob Agents. 2019 Dec;54 (6) :814-819.|J Gastroenterol. 2021 Feb;56 (2) :168-180.|J Neuroimmune Pharmacol. 2017 Dec;12 (4) :682-692.|J Neuroimmune Pharmacol. 2021 Mar;16 (1) :159-168.|Sci Rep. 2019 Nov 20;9 (1) :17158. |Department od Analytical Chemistry, Charles University. 2019 Jun.|Pharmaceuticals (Basel) . 2025 Oct 16;18 (10) :1560.