AQX-016A

AQX-016A is an orally active and potent SHIP1 agonist. AQX-016A can activate recombinant SHIP1 enzyme in vitro and stimulate SHIP1 activity. AQX-016A also can inhibit the PI3K pathway and TNFa production, can be useful for various inflammatory diseases research[1][2].

Product Specifications

CAS Number

[849669-54-1]

UNSPSC

12352005

Target

Phosphatase; PI3K; TNF Receptor

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease; PI3K/Akt/mTOR

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/aqx-016a.html

Purity

99.51

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1=C(O)C2=C(C(C)=C1)[C@]3(C)CC[C@](C(C)(C)CCC4)([H])[C@@]4(C)[C@@]3([H])C2

Molecular Formula

C22H32O2

Molecular Weight

328.49

References & Citations

[1][1]Yau, Tien Yin. Novel strategies for antagonizing the phosphatidylinositol-3-kinase pathway in disease. University of British Columbia. 2010.|[2]Ong CJ, et al. Small-molecule agonists of SHIP1 inhibit the phosphoinositide 3-kinase pathway in hematopoietic cells. Blood. 2007 Sep 15;110 (6) :1942-9.