9-Phenanthrol
9-Phenanthrol (9-Hydroxyphenanthrene) is a selective TRPM4 inhibitor with an IC50 of 17 μM. 9-Phenanthrol has no inhibitory activity on TRPM5, TRPC6, and CFTR. 9-Phenanthrol can be used for the research of ischemia-reperfusion injury[1][2].
Product Specifications
CAS Number
484-17-3
Product Name Alternative
9-Hydroxyphenanthrene; NSC 50554
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/9-phenanthrol.html
Purity
99.61
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC1=CC2=CC=CC=C2C3=CC=CC=C13
Molecular Formula
C14H10O
Molecular Weight
194.23
Precautions
H302, H315, H319, H335
References & Citations
[1]Wang J, et, al. 9-Phenanthrol, a TRPM4 inhibitor, protects isolated rat hearts from ischemia-reperfusion injury. PLoS One. 2013 Jul 25;8 (7) :e70587. |[2]Guinamard R, et al. The TRPM4 channel inhibitor 9-phenanthrol. Br J Pharmacol. 2014 Apr;171 (7) :1600-13.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TRPM4
Available Sizes
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