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EGFR-IN-106

EGFR-IN-106 (compound 6) is a potent EGFR inhibitor with an IC50 value of 0.2396 μM. EGFR-IN-106 shows cytotoxic and anti-inflammatory activity[1].

Product Specifications

UNSPSC

12352005

Target

EGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/egfr-in-106.html

Solubility

10 mM in DMSO

Smiles

NC1=NC2=CC=C(NC(CCN)=O)C=C2C(NC([C@H](C3=CC=C(CC(C)C)C=C3)C)=O)=N1

Molecular Formula

C24H30N6O2

Molecular Weight

434.53

References & Citations

[1]Garduño-Villavicencio LR, et al. Compounds Consisting of Quinazoline, Ibuprofen, and Amino Acids with Cytotoxic and Anti-Inflammatory Effects. ChemMedChem. 2024 Feb 14:e202300651.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

EGFR/ErbB1/HER1

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