PT150
PT150 (ORG-34517) is a competitive and orally active glucocorticoid receptor antagonist. PT150 shows neuroprotective effects. PT150 has the potential for the research of Parkinson’s disease[1][2].
Product Specifications
CAS Number
189035-07-2
Product Name Alternative
ORG-34517
UNSPSC
12352005
Target
Glucocorticoid Receptor
Type
Reference compound
Related Pathways
Immunology/Inflammation; Vitamin D Related/Nuclear Receptor
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pt150.html
Purity
96.70
Smiles
O[C@]1(C#CC)[C@]2(C)[C@H]([C@H](CC3)C([C@@H](C4=CC5=C(C=C4)OCO5)C2)=C6C3=CC(CC6)=O)CC1
Molecular Formula
C28H30O4
Molecular Weight
430.54
References & Citations
[1]Morice C, et al. A randomized trial of safety and pharmacodynamic interactions between a selective glucocorticoid receptor antagonist, PT150, and ethanol in healthy volunteers. Sci Rep. 2021 May 10;11 (1) :9876.|[2]Latham AS, et al. Neuroprotective Efficacy of the Glucocorticoid Receptor Modulator PT150 in the Rotenone Mouse Model of Parkinson's Disease. bioRxiv [Preprint]. 2024 Apr 15:2024.04.12.589261.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
Frequently Asked Questions
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