NOD1/2-IN-1
NOD1/2-IN-1 (Compound 18) is a potent RIPK2 inhibitor with an IC50 value of 1.4 nM, as determined by the ADP-Glo assay. NOD1/2-IN-1 blocks the production of pro-inflammatory cytokines by inhibiting the NOD1/NOD2 pathways, with IC50 values of 18 nM and 170 nM for NOD1 and NOD2, respectively, thereby reducing inflammatory responses. NOD1/2-IN-1 can be used in studies related to colitis[1].
Product Specifications
UNSPSC
12352005
Target
NOD-like Receptor (NLR) ; RIP kinase
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nod1-2-in-1.html
Smiles
COC1=CC2=C(C=C1OCCN(CC)CC)N=CN=C2NC3=CC=C4SC=NC4=C3
Molecular Formula
C22H25N5O2S
Molecular Weight
423.53
References & Citations
[1]Rivoal M, et al. New Potent RIPK2 Inhibitors as a Promising Therapeutic Avenue for Colitis Through the Blockade of NOD Inflammatory Pathways[J]. Journal of Medicinal Chemistry, 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NOD1; NOD2
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