Human CCL2 / MCP-1 Protein, Fc Tag (MALS verified)
Human CCL2, Fc Tag (CC2-H5255) is expressed from human 293 cells (HEK293) . It contains AA Gln 24 - Thr 99 (Accession # P13500-1) .
Product Specifications
Background
Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. CCL2, a member of the CC subfamily, is characterized by two adjacent cysteine residues. CCL2 displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. Elevated expression of the encoded protein is associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
Specifications
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 35.1 kDa. The protein migrates as 40-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Accession Number
P13500-1
Expression Region
Gln 24 - Thr 99
Host
HEK293
Target
CCL2
Conjugation
Unconjugated
Tag
C-Fc
Source
Human
Stability
● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Endotoxin
1.0 EU per μg
Purity
90%
Format
Powder
Buffer
50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
Additives
Trehalose
Molecular Weight
35.1 kDa
Shipping Conditions
RT
Storage Conditions
-20°C
Package Size
50ug*1
Product Datasheet
Https://www.acrobiosystems.com/static/main/products/pdf/ds/CC2-H5255.pdf
Species
Human
Curated Selection
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