Thalidomide-5-COOH
Thalidomide-5-COOH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-COOH can be connected to the ligand for protein by a linker to form PROTACs[1].
Product Specifications
CAS Number
[1216805-11-6]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Autophagy; Ligands for E3 Ligase
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/thalidomide-5-cooh.html
Purity
99.94
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(C1=CC2=C(C(N(C(CC3)C(NC3=O)=O)C2=O)=O)C=C1)O
Molecular Formula
C14H10N2O6
Molecular Weight
302.24
Precautions
H302, H315, H319, H335
References & Citations
[1]Liu K, et, al. Design and biological characterization of hybrid compounds of curcumin and thalidomide for multiple myeloma. Org Biomol Chem. 2013 Aug 7;11 (29) :4757-63.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
GTR15128848 1 Vial
Lentiviral human LLGL1 shRNA (UAS) - Lentiviral human LLGL1 shRNA (UAS, iRFP) plasmid
Ask
View Details 
127968-HRP 100 µL
HMX2 (Homeobox Protein HMX2, Homeobox Protein H6 Family Member 2) (HRP)
Ask
View Details 
RC200503L3V 200 µL
Apolipoprotein D (APOD) (NM_001647) Human Tagged ORF Clone Lentiviral Particle
Ask
View Details