GLPG1837

GLPG1837 is a potent and reversible CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.

Product Specifications

CAS Number

[1654725-02-6]

Product Name Alternative

ABBV-974

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; CFTR

Type

Reference compound

Related Pathways

Autophagy; Membrane Transporter/Ion Channel

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/GLPG1837.html

Purity

99.87

Solubility

DMSO : ≥ 250 mg/mL

Smiles

O=C(C1=NNC=C1)NC(S2)=C(C(N)=O)C3=C2C(C)(C)OC(C)(C)C3

Molecular Formula

C16H20N4O3S

Molecular Weight

348.42

Precautions

H302, H315, H319, H335

References & Citations

[1]Van der Plas SE, et al. Discovery of N- (3-Carbamoyl-5,5,7,7-tetramethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-2-yl) -lH-pyrazole-5-carboxamide (GLPG1837), a Novel Potentiator Which Can Open Class III Mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Channels to a High Extent. J Med Chem. 2018 Feb 22;61 (4) :1425-1435.|[2]Yeh HI, et al. A common mechanism for CFTR potentiators. J Gen Physiol. 2017 Dec 4;149 (12) :1105-1118.