GLPG1837
GLPG1837 is a potent and reversible CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.
Product Specifications
CAS Number
[1654725-02-6]
Product Name Alternative
ABBV-974
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; CFTR
Type
Reference compound
Related Pathways
Autophagy; Membrane Transporter/Ion Channel
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/GLPG1837.html
Purity
99.87
Solubility
DMSO : ≥ 250 mg/mL
Smiles
O=C(C1=NNC=C1)NC(S2)=C(C(N)=O)C3=C2C(C)(C)OC(C)(C)C3
Molecular Formula
C16H20N4O3S
Molecular Weight
348.42
Precautions
H302, H315, H319, H335
References & Citations
[1]Van der Plas SE, et al. Discovery of N- (3-Carbamoyl-5,5,7,7-tetramethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-2-yl) -lH-pyrazole-5-carboxamide (GLPG1837), a Novel Potentiator Which Can Open Class III Mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Channels to a High Extent. J Med Chem. 2018 Feb 22;61 (4) :1425-1435.|[2]Yeh HI, et al. A common mechanism for CFTR potentiators. J Gen Physiol. 2017 Dec 4;149 (12) :1105-1118.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
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