Propargyl-PEG4-Tos

Propargyl-PEG4-Tos is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-Tos is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1][2]. Propargyl-PEG4-Tos is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[875770-32-4]

UNSPSC

12352203

Hazard Statement

H315, H319

Target

ADC Linker; PROTAC Linkers

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/propargyl-peg4-tos.html

Purity

99.25

Solubility

10 mM in DMSO

Smiles

C#CCOCCOCCOCCOCCOS(C1=CC=C(C)C=C1)(=O)=O

Molecular Formula

C18H26O7S

Molecular Weight

386.46

Precautions

H315, H319

References & Citations

[1]Wurz RP, et al. A "Click Chemistry Platform" for the Rapid Synthesis of Bispecific Molecules for Inducing ProteinDegradation. J Med Chem. 2018 Jan 25;61 (2) :453-461.|[2]Senthilkumar T, et al. Conjugated Polymer Nanoparticles with Appended Photo-Responsive Units for Controlled DrugDelivery, Release, and Imaging. Angew Chem Int Ed Engl. 2018 Oct 1;57 (40) :13114-13119.