Tadalafil-d3

Tadalafil-d3 is the deuterium labeled Nortadalafil. Nortadalafil is demethyl Tadalafil, which is a PDE5 inhibitor, currently marketed in pill form for treating erectile dysfunction (ED) under the name Cialis; and under the name Adcirca for the treatment of pulmonary arterial hypertension.

Product Specifications

CAS Number

[960226-55-5]

Product Name Alternative

IC-351-d3

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Phosphodiesterase (PDE)

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cardiovascular Disease

Purity

99.40

Solubility

DMSO : 50mg/mL (ultrasonic)

Smiles

O=C1N2[C@@](C3=CC=C(OCO4)C4=C3)([H])C5=C(C[C@]2([H])C(N(C1)C([2H])([2H])[2H])=O)C6=CC=CC=C6N5

Molecular Formula

C22H16D3N3O4

Molecular Weight

392.42

Precautions

H315, H319, H335

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Beghyn, et al. PDE5 inhibitors: An original access to novel potent arylated analogues of tadalafil. Bioorganic & Medicinal Chemistry Letters (2007), 17 (3), 789-792.|[3]Daugan, et al. The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione analogue. Journal of Medicinal Chemistry (2003), 46 (21), 4533-4542.|[4]Porst H, et al. Chronic PDE-5 inhibition in patients with erectile dysfunction - a treatment approach using tadalafil once-daily. Expert Opin Pharmacother. 2012 Jul;13 (10) :1481-94.|[5]Frey MK, Lang I. Tadalafil for the treatment of pulmonary arterial hypertension. Expert Opin Pharmacother. 2012 Apr;13 (5) :747-55.