AR antagonist 6
AR antagonist 6 (compound 6i) is a diphenyl ether androgen receptor (AR) antagonist that binds AR at a concentration of 120 nM. AR antagonist 6 exhibits low toxicity and in vitro activity against the golden Syrian hamster ear model[1].
Product Specifications
CAS Number
876760-08-6
UNSPSC
12352005
Target
Androgen Receptor
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/ar-antagonist-6.html
Solubility
10 mM in DMSO
Smiles
N#CC1=CC=C(C=C1C(F)(F)F)OC2=C(OCC)C=CC=C2
Molecular Formula
C16H12F3NO2
Molecular Weight
307.27
References & Citations
[1]Mitchell LH, et al. Diphenyl ethers as androgen receptor antagonists for the topical suppression of sebum production. Bioorg Med Chem Lett. 2009 Apr 15;19 (8) :2176-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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