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AR antagonist 6

AR antagonist 6 (compound 6i) is a diphenyl ether androgen receptor (AR) antagonist that binds AR at a concentration of 120 nM. AR antagonist 6 exhibits low toxicity and in vitro activity against the golden Syrian hamster ear model[1].

Product Specifications

CAS Number

876760-08-6

UNSPSC

12352005

Target

Androgen Receptor

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/ar-antagonist-6.html

Solubility

10 mM in DMSO

Smiles

N#CC1=CC=C(C=C1C(F)(F)F)OC2=C(OCC)C=CC=C2

Molecular Formula

C16H12F3NO2

Molecular Weight

307.27

References & Citations

[1]Mitchell LH, et al. Diphenyl ethers as androgen receptor antagonists for the topical suppression of sebum production. Bioorg Med Chem Lett. 2009 Apr 15;19 (8) :2176-8.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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