CCR8 antagonist 2
CCR8 antagonist 2 is a potent antagonist of CCR8. CCR8 (C-C Motif Chemokine Receptor 8) is predominantly expressed on Treg cells and Th2 cells, but not on Th1 cells. CCR8 antagonist 2 inhibits CCR8 activity, which may be used in the research of diseases mediated by CCR8, such as cancer, and/or neuropathic pain (extracted from patent WO2022000443A1, compound 220) [1].
Product Specifications
CAS Number
[2756350-98-6]
UNSPSC
12352005
Target
CCR
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ccr8-antagonist-2.html
Purity
98.34
Solubility
DMSO : 4 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(NC1=C(C)C=C(S(=O)(N[C@@H](C2CCN(C)CC2)C)=O)C=C1Cl)C3=CC=CC=C3C
Molecular Formula
C23H30ClN3O3S
Molecular Weight
464.02
References & Citations
[1]Guohuang FAN, et al. Methods and compositions for targeting tregs using ccr8 inhibitors.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CCR8
Available Sizes
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