1-Hydroxypyrene

1-Hydroxypyrene, a biomarker of exposure to polycyclic aromatic hydrocarbons (PAHs), is analyzed in urine samples. 1-Hydroxypyrene is the major biomarker of exposure to pyrenes. 1-Hydroxypyrene is the orally active agonist for aryl hydrocarbon receptor (AhR) and can lead to renal fibrosis[1][2].

Product Specifications

CAS Number

[5315-79-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Aryl Hydrocarbon Receptor; Collagen; Cytochrome P450

Type

Natural Products

Related Pathways

Cytoskeleton; Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/1-hydroxypyrene.html

Purity

99.84

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

OC1=C(C2=C34)C=CC4=CC=CC3=CC=C2C=C1

Molecular Formula

C16H10O

Molecular Weight

218.25

Precautions

H302, H315, H319, H335

References & Citations

[1]Fernando Freitas, et al. Urinary 1-hydroxypyrene Is Associated With Oxidative Stress and Inflammatory Biomarkers in Acute Myocardial Infarction. Int J Environ Res Public Health|[2]Miao H, et al., 1-Hydroxypyrene mediates renal fibrosis through aryl hydrocarbon receptor signalling pathway. Br J Pharmacol. 2022 Jan;179 (1) :103-124.