Octoclothepin (maleate salt)

Octoclothepin maleate salt, an orally active neuroleptic agent, is a dual SR-2A and D2DR inhibitor. Octoclothepin maleate salt reveals an intensive central depressant action in a series of observational and instrumental procedures in rodents[1][2].

Product Specifications

CAS Number

[4789-68-8]

Product Name Alternative

Clorotepine (maleate salt)

UNSPSC

12352005

Hazard Statement

H301

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/octoclothepin-maleate-salt.html

Purity

99.14

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CN1CCN(C2CC3=CC=CC=C3SC4=CC=C(Cl)C=C24)CC1.O=C(O)/C=C\C(O)=O

Molecular Formula

C23H25ClN2O4S

Molecular Weight

460.97

Precautions

H301

References & Citations

[1]J Metysová, et al. Pharmacological properties of a potent neuroleptic drug octoclothepin. Acta Biol Med Ger. 1980;39 (6) :723-40.|[2]J Hyttel, et al. Characterization of binding of 3H-SCH 23390 to dopamine D-1 receptors. Correlation to other D-1 and D-2 measures and effect of selective lesions. J Neural Transm. 1987;68 (3-4) :171-89.