BAX Polyclonal Antibody
Product Specifications
Background
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.
Abbreviation
BAX
UniProt
Q07812
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant Human BAX Protein expressed by E.coli
Target
Apoptosis regulator BAX; Bcl-2-like protein 4 (Bcl2-L-4) ; BAX; BCL2L4
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB
Field of Research
Cancer; Cell Biology; Metabolism
Purification
Antigen Affinity Purification
Concentration
1 mg/mL
Dilution
WB 1:500-1:1000
Buffer
PBS with 0.02% sodium azide,1% protective protein and 50% glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
4 kDa/12 kDa/15 kDa/18 kDa/19 kDa/21 kDa/24 kDa
Observed Molecular Weight
20 kDa
Isotype
IgG
Available Sizes
Documents
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