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IL-2R alpha/CD25, Human (HEK293, His-Avi)

Selected Variant

HY-P78412

Size: 1 Each

IL-2R alpha (CD25) is an essential component of high-affinity IL-2 receptors. IL-2R alpha enhances binding of IL-2 to its receptor complex so that regulates T cell growth and other lymphoid functions[1][2]. IL-2R alpha/CD25 Protein, Human (HEK293, His-Avi) is a recombinant human IL-2R alpha protein with a His tag and an Avi tag at the C-terminus and is expressed in HEK293 cells. It consists of 192 amino acids (E22-C213) .

Product Specifications

Product Name Alternative

IL-2R alpha/CD25 Protein, Human (HEK293, His-Avi), Human, HEK293

UNSPSC

12352202

Type

Recombinant Proteins

Assay Protocol

https://www.medchemexpress.com/cytokines/il-2r-alpha-cd25-protein-human-hek293-his-avi.html

Molecular Formula

3559 (Gene_ID) P01589 (E22-C213) (Accession)

Molecular Weight

Approximately 40-50 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

References & Citations

[1]H.Asao. Interleukin-2. Reference Module in Biomedical Sciences. 2014. ISBN 9780128012383.|[2]Kim HP, et al. The basis for IL-2-induced IL-2 receptor alpha chain gene regulation: importance of two widely separated IL-2 response elements. Immunity. 2001 Jul;15 (1) :159-72.|[3]Bell CJ, et al. Sustained in vivo signaling by long-lived IL-2 induces prolonged increases of regulatory T cells. J Autoimmun. 2015 Jan;56:66-80.|[4]Chistiakov DA, et al. The crucial role of IL-2/IL-2RA-mediated immune regulation in the pathogenesis of type 1 diabetes, an evidence coming from genetic and animal model studies. Immunol Lett. 2008 Jun 15;118 (1) :1-5.

Shipping Conditions

Room temperature in continental US; may vary elsewhere.

Scientific Category

Recombinant Proteins

Price

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