Lofexidine
Lofexidine is a selective α2-receptor agonist, commonly used to alleviate the physical symptoms of heroin and other types of opioid withdrawal[1][2].
Product Specifications
CAS Number
[31036-80-3]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/Lofexidine.html
Purity
99.08
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
CC(C1=NCCN1)OC2=C(Cl)C=CC=C2Cl
Molecular Formula
C11H12Cl2N2O
Molecular Weight
259.13
Precautions
H302, H315, H319, H335
References & Citations
[1]Vartak AP, et al. The preclinical discovery of lofexidine for the treatment of opiate addiction. Expert Opin Drug Discov. 2014 Nov;9 (11) :1371-7.|[2]Gish EC, et al. Lofexidine, an {alpha}2-receptor agonist for opioid detoxification. Ann Pharmacother. 2010 Feb;44 (2) :343-51.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
α adrenergic receptor
Available Sizes
Curated Selection
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