Lofexidine

Lofexidine is a selective α2-receptor agonist, commonly used to alleviate the physical symptoms of heroin and other types of opioid withdrawal[1][2].

Product Specifications

CAS Number

[31036-80-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/Lofexidine.html

Purity

99.08

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

CC(C1=NCCN1)OC2=C(Cl)C=CC=C2Cl

Molecular Formula

C11H12Cl2N2O

Molecular Weight

259.13

Precautions

H302, H315, H319, H335

References & Citations

[1]Vartak AP, et al. The preclinical discovery of lofexidine for the treatment of opiate addiction. Expert Opin Drug Discov. 2014 Nov;9 (11) :1371-7.|[2]Gish EC, et al. Lofexidine, an {alpha}2-receptor agonist for opioid detoxification. Ann Pharmacother. 2010 Feb;44 (2) :343-51.