AS-1669058 (free base)
AS-1669058 free base is a GPR119 agonist and a potential inhibitor of type 2 diabetes. AS-1669058 free base induces insulin secretion induced by high blood glucose levels in vitro and in vivo and increases insulin promoter activity. In animal studies, AS-1669058 free base improved glucose tolerance and reduced blood glucose levels in db/db mice.
Product Specifications
CAS Number
1395553-31-7
UNSPSC
12352005
Target
GPR119
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/as-1669058-free-base.html
Smiles
[O-][N+]1=CC=CC(CCNC2=NC(C3=CC(F)=C(Br)C=C3F)=NC(C)=C2)=C1
Molecular Formula
C18H15BrF2N4O
Molecular Weight
421.24
References & Citations
[1]Novel GPR119 agonist AS1669058 potentiates insulin secretion from rat islets and has potent anti-diabetic effects in ICR and diabetic db/db mice
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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