PB94

PB94 is a selective HDAC11 inhibitor (IC50=108 nM) . PB94 can be radiolabeled as [11C]-PB94 for use in positron emission tomography (PET), as well as brain uptake and metabolic properties in administered live animals. PB94 improves neuropathic pain in mice and could be used to study neurological indications[1].

Product Specifications

CAS Number

[3032970-74-1]

UNSPSC

12352005

Target

HDAC

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pb94.html

Purity

97.04

Solubility

DMSO : 87.5 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=C2C(C=CN2CC(C=C3)=CC(OC)=C3C(NO)=O)=C1)NCC4(C[C@@H](C5)C6)C[C@@H]6C[C@@H]5C4

Molecular Formula

C29H33N3O4

Molecular Weight

487.59

References & Citations

[1]Bai P et al. Development and Pharmacochemical Characterization Discover a Novel Brain-Permeable HDAC11-Selective Inhibitor with Therapeutic Potential by Regulating Neuroinflammation in Mice. J Med Chem. 2023 Nov 16.