Oleandrigenin

Oleandrigenin is a potent cardiotonic steroid. Oleandrigenin shows Na+/K+-ATP-ase inhibiting and cytotoxic activities[1][2].

Product Specifications

CAS Number

[465-15-6]

UNSPSC

12352005

Target

Na+/K+ ATPase

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Cancer; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/oleandrigenin.html

Solubility

10 mM in DMSO

Smiles

O[C@@]12[C@@]([C@@H](C3=CC(OC3)=O)[C@H](C1)OC(C)=O)(CC[C@@]4([H])[C@@]2([H])CC[C@@]5([H])[C@@]4(CC[C@@H](C5)O)C)C

Molecular Formula

C25H36O6

Molecular Weight

432.55

References & Citations

[1]Fejedelem Z, et al. Synthesis of Cardiotonic Steroids Oleandrigenin and Rhodexin B. J Org Chem. 2021 Aug 6;86 (15) :10249-10262. |[2]Michalak K, et al. Synthesis and evaluation of Na+/K+-ATP-ase inhibiting and cytotoxic in vitro activities of oleandrigenin and its selected 17β- (butenolidyl) - and 17β- (3-furyl) - analogues. Eur J Med Chem. 2020 Sep 15;202:112520.