Oleandrigenin
Product Specifications
UNSPSC Description
Oleandrigenin is a potent cardiotonic steroid. Oleandrigenin shows Na+/K+-ATP-ase inhibiting and cytotoxic activities[1][2].
Target Antigen
Na+/K+ ATPase
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/oleandrigenin.html
Solubility
10 mM in DMSO
Smiles
O[C@@]12[C@@]([C@@H](C3=CC(OC3)=O)[C@H](C1)OC(C)=O)(CC[C@@]4([H])[C@@]2([H])CC[C@@]5([H])[C@@]4(CC[C@@H](C5)O)C)C
Molecular Weight
432.55
References & Citations
[1]Fejedelem Z, et al. Synthesis of Cardiotonic Steroids Oleandrigenin and Rhodexin B. J Org Chem. 2021 Aug 6;86(15):10249-10262. |[2]Michalak K, et al. Synthesis and evaluation of Na+/K+-ATP-ase inhibiting and cytotoxic in vitro activities of oleandrigenin and its selected 17β-(butenolidyl)- and 17β-(3-furyl)- analogues. Eur J Med Chem. 2020 Sep 15;202:112520.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N11690/Oleandrigenin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N11690/
Clinical Information
No Development Reported
CAS Number
465-15-6
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