DNA2 inhibitor C5
DNA2 inhibitor C5 is a potent, competitive, and specific DNA2 nuclease inhibitor with an IC50 of 20 μM. DNA2 inhibitor C5 inhibits the nuclease, DNA-dependent ATPase, helicase, and DNA-binding activities of DNA2. DNA2 inhibitor C5 can be used in breast cancer and colorectal cancer research[1].
Product Specifications
CAS Number
[35973-25-2]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dna2-inhibitor-c5.html
Purity
98.51
Solubility
DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=C(O)C2=CC=CC([N+]([O-])=O)=C2N=C1)O
Molecular Formula
C10H6N2O5
Molecular Weight
234.17
Precautions
H302, H315, H319, H335
References & Citations
[1]Binghui Shen, et al. Dna2 inhibitors for cancer treatment. US20170226063A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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