AAK1-IN-6
AAK1-IN-6 (Compound 23) is an inhibitor of AP-2-associated protein kinase 1 (AAK1, IC50 = 12 nM) with antiviral activity against the dengue virus (DNEV2, EC50 = 0.24 μM) and Venezuelan equine encephalitis virus (VEEV, EC50 = 0.30 μM) . AAK1-IN-6 can be utilized in antiviral research[1].
Product Specifications
CAS Number
3061058-16-7
UNSPSC
12352005
Target
AAK1; Dengue Virus
Type
Reference compound
Related Pathways
Anti-infection; Neuronal Signaling
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/aak1-in-6.html
Smiles
COC1=C(OC)C=C(C2=CN=C(NC=C3C4=CN=C(C5=CC=CC=C5)O4)C3=C2)C=C1
Molecular Formula
C24H19N3O3
Molecular Weight
397.43
References & Citations
[1]Ravi NP, et al. Synthesis of 3-heteroaryl-pyrrolo[2,3-b]pyridines as potent inhibitors of AP-2-associated protein kinase 1 (AAK1) with antiviral activity. Eur J Med Chem. 2024 Dec 15;280:116967.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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