Ispronicline

Ispronicline (TC-1734), an orally active, brain-selective α4β2 nicotine acetylcholine receptor (nAChR) partial agonist, has shown memory-enhancing properties in rodents and a good tolerability profile. Ispronicline binds to the α4β2 nAChR with high affinity (Ki=11 nM) and is highly selective to other nAChRs such as α7 nAChR and α3β4 nAChR[1][2].

Product Specifications

CAS Number

[252870-53-4]

Product Name Alternative

TC-1734; ACD3480

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

NAChR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ispronicline.html

Purity

98.24

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@H](NC)C/C=C/C1=CC(OC(C)C)=CN=C1

Molecular Formula

C14H22N2O

Molecular Weight

234.34

Precautions

H302, H315, H319, H335

References & Citations

[1]Julie Jacobsen, et al. The α4β2 nicotine acetylcholine receptor agonist ispronicline induces c-Fos expression in selective regions of the rat forebrain. Neurosci Lett. 2012 Apr 25;515 (1) :7-11.