Salviolone
Salviolone is a natural diterpenoid derivative that can against melanoma cells. Salviolone exhibits a pleiotropic effect against melanoma by hampering cell cycle progression, STAT3 signaling, and malignant phenotype of A375 melanoma cells[1].
Product Specifications
CAS Number
[119400-86-1]
UNSPSC
12352005
Target
STAT
Type
Natural Products
Related Pathways
JAK/STAT Signaling; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/salviolone.html
Purity
99.32
Solubility
10 mM in DMSO
Smiles
O=C1C(C)=CC2=CC=C3C(C)(C)CCCC3=C2C=C1O
Molecular Formula
C18H20O2
Molecular Weight
268.35
References & Citations
[1]Valentina Zanrè, et al. Salviolone from Salvia miltiorrhiza Roots Impairs Cell Cycle Progression, Colony Formation, and Metalloproteinase-2 Activity in A375 Melanoma Cells: Involvement of P21 (Cip1/Waf1) Expression and STAT3 Phosphorylation. Int J Mol Sci. 2022 Jan 20;23 (3) :1121.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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