CLIP (86-100) (TFA)

CLIP (86-100) TFA is amino acids 86 to 100 fragment of class II-associated invariant chain peptide (CLIP) . CLIP is a small self-peptide and cleavage product of the invariant chain that resides in the HLA-II antigen binding groove and is believed to play a critical role in the assembly and transport of MHC class II alphabetaIi complexes through its interaction with the class II peptide-binding site[1].

Product Specifications

UNSPSC

12352209

Target

Others

Type

Peptides

Related Pathways

Others

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/clip-86-100-tfa.html

Solubility

10 mM in DMSO

Smiles

OC(C(F)(F)F)=O.O=C([C@@H]1CCCN1)N[C@@H](C(C)C)C(N[C@@H](CO)C(N[C@@H](CCCCN)C(N[C@@H](CCSC)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCSC)C(N[C@@H](C)C(N[C@@H]([C@H](O)C)C(N2[C@@H](CCC2)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCSC)C(N[C@@H](CCC(N)=O)C(N[C@@H](C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C72H128N20O19S3.xC2HF3O2

Molecular Weight

1674.10 (free acid)

References & Citations

[1]van Luijn MM, et al. Class II-associated invariant chain peptide as predictive immune marker in minimal residual disease in acute myeloid leukemia. Oncoimmunology. 2015 Jan 7;3 (12) :e941737. eCollection 2014 Dec.|[2]Thayer WP, et al. Class II-associated invariant chain peptide-independent binding of invariant chain to class II MHC molecules. J Immunol. 1999 Feb 1;162 (3) :1502-9.