SQA1
SQA1, a squaramide (SQA) derivative, is a CCR6 antagonist with a Kd of 250 nM. SQA1 is also a CXCR2 inhibitor. The intracellular pocket occupied by SQA1 overlaps with the G protein binding site and stabilizes the closed conformation of the intracellular pocket[1].
Product Specifications
CAS Number
1255915-27-5
UNSPSC
12352005
Target
CCR; CXCR
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sqa1.html
Smiles
OC1=C(NC2=C(N[C@H](CC)C3=CC(C(C)C)=CO3)C(C2=O)=O)C=CN=C1C(N(C)C)=O
Molecular Formula
C22H26N4O5
Molecular Weight
426.47
References & Citations
[1]David Jonathan Wasilko, et al. Structural basis for CCR6 modulation by allosteric antagonists. bioRxiv. April 06, 2024
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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