Fuscin

Fuscin, a fungal metabolite, CCR5 receptor antagonist with anti-HIV effects. Fuscin is a respiration and oxidative phosphorylation inhibitor, and also a mitochondrial SH-dependent transport-linked functions inhibitor[1][2][3].

Product Specifications

CAS Number

[83-85-2]

UNSPSC

12352005

Hazard Statement

H302+H312+H332

Target

Bacterial; CCR; Endogenous Metabolite; HIV; Mitochondrial Metabolism; Oxidative Phosphorylation

Type

Natural Products

Related Pathways

Anti-infection; GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Infection; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/fuscin.html

Solubility

10 mM in DMSO

Smiles

O=C1C=C2C(C(C)O1)=C(O)C(C3=C2CCC(C)(C)O3)=O

Molecular Formula

C15H16O5

Molecular Weight

276.28

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501

References & Citations

[1]K Yoganathan, et al. 10-Methoxydihydrofuscin, fuscinarin, and fuscin, novel antagonists of the human CCR5 receptor from Oidiodendron griseum. J Nat Prod. 2003 Aug;66 (8) :1116-7. |[2]K S Cheah. Fuscin, an inhibitor of respiration and oxidative phosphorylation in ox-neck muscle mitochondria. Biochim Biophys Acta.1972 Jul 12;275 (1) :1-9. |[3]P M Vignais, et al. Fuscin, an inhibitor of mitochondrial SH-dependent transport-linked functions. Biochim Biophys Acta. 1973 Dec 14;325 (3) :357-74.