Fuscin
Product Specifications
UNSPSC Description
Fuscin, a fungal metabolite, CCR5 receptor antagonist with anti-HIV effects. Fuscin is a respiration and oxidative phosphorylation inhibitor, and also a mitochondrial SH-dependent transport-linked functions inhibitor[1][2][3].
Target Antigen
Bacterial; CCR; Endogenous Metabolite; HIV; Mitochondrial Metabolism; Oxidative Phosphorylation
Type
Natural Products
Related Pathways
Anti-infection;GPCR/G Protein;Immunology/Inflammation;Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Infection; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/fuscin.html
Solubility
10 mM in DMSO
Smiles
O=C1C=C2C(C(C)O1)=C(O)C(C3=C2CCC(C)(C)O3)=O
Molecular Weight
276.28
References & Citations
[1]K Yoganathan, et al. 10-Methoxydihydrofuscin, fuscinarin, and fuscin, novel antagonists of the human CCR5 receptor from Oidiodendron griseum. J Nat Prod. 2003 Aug;66(8):1116-7. |[2]K S Cheah. Fuscin, an inhibitor of respiration and oxidative phosphorylation in ox-neck muscle mitochondria. Biochim Biophys Acta.1972 Jul 12;275(1):1-9. |[3]P M Vignais, et al. Fuscin, an inhibitor of mitochondrial SH-dependent transport-linked functions. Biochim Biophys Acta. 1973 Dec 14;325(3):357-74.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-111321/Fuscin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-111321/
Clinical Information
No Development Reported
CAS Number
83-85-2
Available Sizes
Curated Selection
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