KIF18A-IN-14
Product Specifications
UNSPSC Description
KIF18A-IN-14 (Compound Example 81) is a KIF18A inhibitor. KIF18A-IN-14 is available in two forms, EX81-A and its enantiomer EX81-B. EX81-A and EX81-B inhibit OVCAR-3 cells viability with IC50s of 0-0.01 μM and 0.01-0.1 μM, respectively. KIF18A-IN-14 can be used in tumor (e.g. colon, breast, lung) studies[1].
Target Antigen
Kinesin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/kif18a-in-14.html
Smiles
O=C1NC2=CC=CC(N3CCOC(C3)COCC4(C(F)(F)F)CCN(CC4)C5=CC(NS(=O)(CCO)=O)=CC=C15)=N2
Molecular Weight
599.62
References & Citations
[1]Ding, et al. Inhibitors of kif18a and uses thereof. WO2024153217.WIPO, 2024-01-19.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-164978/KIF18A-IN-14-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-164978/
Clinical Information
No Development Reported
CAS Number
3051552-75-8
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