HC-056456
HC-056456 is an effective but not perfectly-selective blocker of CatSper channels. The [Na+]i rise is slowed by HC-056456 (IC50~3 µM) .
Product Specifications
CAS Number
7733-96-2
Product Name Alternative
3,4-Bis (2-thienoyl) -1,2,5-oxadiazole-N-oxide
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Calcium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/HC-056456.html
Purity
98.00
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
[O-][N+]1=C(C(C2=CC=CS2)=O)C(C(C3=CC=CS3)=O)=NO1
Molecular Formula
C12H6N2O4S2
Molecular Weight
306.32
Precautions
H302, H315, H319, H335
References & Citations
[1]Carlson AE, et al. Pharmacological targeting of native CatSper channels reveals a required role in maintenance of sperm hyperactivation. PLoS One. 2009 Aug 31;4 (8) :e6844.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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