Human TSH alpha/beta Heterodimer Protein, His Tag

Thyroid-stimulating hormone (also known as thyrotropin, thyrotropic hormone, or abbreviated TSH) is a pituitary hormone that stimulates. It is a glycoprotein hormone produced by thyrotrope cells in the anterior pituitary gland, which regulates the endocrine function of the thyroid. Thyroid stimulating hormone consists of two subunits called alpha and beta. The alpha and beta subunits are bound together to produce the active form of the hormone. The α subunit is thought to be the effector region responsible for stimulation of adenylate cyclase (involved the generation of cAMP) .The β (beta) subunit (TSHB) is unique to TSH, and therefore determines its receptor specificity.

Product Specifications

Background

Specifications

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 28.4 kDa. The protein migrates as 43-48 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Accession Number

P01215-1 (TSH alpha) & P01222-1 (TSH beta)

Expression Region

Phe 21 - Val 138 (TSH beta) & Ala 25 - Ser 116 (TSH alpha)

Host

HEK293

Target

TSH alpha/beta Heterodimer

Conjugation

Unconjugated

Tag

C-10xHis | Native

Source

Human

Stability

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.