EM127
EM127 (compound 11c) is a SMYD3 covalent inhibitor with high selectivity, high affinity (KD=13 μM) and site-specificity. EM127 effectively inhibits ERK1/2 phosphorylation and reduces transcriptional regulation of SMYD3 target genes. EM127 effectively and prolongedly impairs methyltransferase activity. EM127 can be used in cancer research, particularly in SMYD3 positive tumours[1].
Product Specifications
CAS Number
[1886879-71-5]
UNSPSC
12352005
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/em127.html
Purity
99.94
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=NOC(C2CC2)=C1)NC3CCN(C(CCl)=O)CC3
Molecular Formula
C14H18ClN3O3
Molecular Weight
311.76
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SMYD3
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
RPUSD1, ID (RPUSD1, C16orf40, RLUCL, RNA pseudouridylate synthase domain-containing protein 1, Ribosomal large subunit pseudouridine synthase C-like protein) (APC) discontinued
Kappa Light Chain (HCAK1, Ig kappa Chain C Region, IGKC, Immunoglobulin kappa Constant Region, Immunoglobulin kappa Light Chain, Kappa 1 Immunoglobulin Light Chain, Km, MGC111575, MGC62011, MGC72072, MGC88770, MGC88771, MGC88809) (MaxLight 650) discontinued
