β-Glucocerebrosidase modulator 1
β-Glucocerebrosidase modulator 1 (Compound 28) is an allosteric modulator for β-Glucocerebrosidase with an EC50 of 9.0 μM and a Kd of 0.050 μM[1].
Product Specifications
CAS Number
[3080715-77-8]
UNSPSC
12352005
Target
Glycosidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/β-glucocerebrosidase-modulator-1.html
Purity
99.01
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CN(C[C@@H](C1=CC(C(C)=C)=CC=C1)N)S(C2=CC(F)=CC(F)=C2)(=O)=O
Molecular Formula
C18H20F2N2O2S
Molecular Weight
366.43
References & Citations
[1]Palmer N, et al., Fragment-Based Discovery of a Series of Allosteric-Binding Site Modulators of β-Glucocerebrosidase. J Med Chem. 2024 Jul 11;67 (13) :11168-11181.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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