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β-Glucocerebrosidase modulator 1

β-Glucocerebrosidase modulator 1 (Compound 28) is an allosteric modulator for β-Glucocerebrosidase with an EC50 of 9.0 μM and a Kd of 0.050 μM[1].

Product Specifications

CAS Number

3080715-77-8

UNSPSC

12352005

Target

Glycosidase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/β-glucocerebrosidase-modulator-1.html

Purity

99.01

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CN(C[C@@H](C1=CC(C(C)=C)=CC=C1)N)S(C2=CC(F)=CC(F)=C2)(=O)=O

Molecular Formula

C18H20F2N2O2S

Molecular Weight

366.43

References & Citations

[1]Palmer N, et al., Fragment-Based Discovery of a Series of Allosteric-Binding Site Modulators of β-Glucocerebrosidase. J Med Chem. 2024 Jul 11;67 (13) :11168-11181.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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